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- Title
Susceptible and protective associations of HLA DRB1*/ DQB1* alleles and haplotypes with ischaemic stroke.
- Authors
Murali, V.; Rathika, C.; Ramgopal, S.; Padma Malini, R.; Arun Kumar, M. J.; Neethi Arasu, V.; Jeyaram Illiayaraja, K.; Balakrishnan, K.
- Abstract
Stroke has emerged as the second commonest cause of mortality worldwide and is a major public health problem. For the first time, we present here the association of human leucocyte antigen ( HLA)- DRB1*/ DQB1* alleles and haplotypes with ischaemic stroke in South Indian patients. Ischaemic stroke ( IS) cases and controls were genotyped for HLA- DRB1*/ DQB1* alleles by polymerase chain reaction sequence-specific primers ( PCR- SSP) method. The frequencies of HLA class II alleles such as DRB1*04, DRB1*07, DRB1*11, DRB1*12, DRB1*13, DQB1*02 and DQB1*07 were high in IS patients than in the age- and gender-matched controls, suggesting that the individuals with these alleles are susceptible to ischaemic stroke in South India. The frequencies of alleles such as DRB1*03, DRB1*10, DRB1*14, DQB1*04 and DQB1*05 were less in IS cases than in the controls, suggesting a protective association. Haplotypes DRB1*04- DQB1*0301, DRB1*07- DQB1*02, DRB1*07- DQB1*0301, DRB1*11- DQB1*0301 and DRB1*13- DQB1*06 were found to be high in IS patients conferring susceptibility. The frequency of haplotype DRB1*10- DQB1*05 was high in controls conferring protection. IS- LVD and gender-stratified analysis too confirmed these susceptible and protective associations. Thus, HLA- DRB1*/ DQB1* alleles and haplotypes strongly predispose South Indian population to ischaemic stroke. Further studies in different populations with large sample size or the meta-analysis are needed to explain the exact mechanism of associations of HLA gene(s) with IS.
- Subjects
STROKE; MORTALITY; ATHEROSCLEROSIS; HUMAN leucocytes; ALLELES; ANTIGEN synthesis
- Publication
International Journal of Immunogenetics, 2016, Vol 43, Issue 3, p159
- ISSN
1744-3121
- Publication type
Article
- DOI
10.1111/iji.12266