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- Title
Microbial Contamination in Next Generation Sequencing: Implications for Sequence-Based Analysis of Clinical Samples.
- Authors
Strong, Michael J.; Xu, Guorong; Morici, Lisa; Splinter Bon-Durant, Sandra; Baddoo, Melody; Lin, Zhen; Fewell, Claire; Taylor, Christopher M.; Flemington, Erik K.
- Abstract
The high level of accuracy and sensitivity of next generation sequencing for quantifying genetic material across organismal boundaries gives it tremendous potential for pathogen discovery and diagnosis in human disease. Despite this promise, substantial bacterial contamination is routinely found in existing human-derived RNA-seq datasets that likely arises from environmental sources. This raises the need for stringent sequencing and analysis protocols for studies investigating sequence-based microbial signatures in clinical samples.
- Subjects
MICROBIAL contamination; PATHOGENIC microorganisms; RNA sequencing; NUCLEOTIDE sequence; NUCLEOTIDE sequencing
- Publication
PLoS Pathogens, 2014, Vol 10, Issue 11, p1
- ISSN
1553-7366
- Publication type
Article
- DOI
10.1371/journal.ppat.1004437