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- Title
Radical triads, not pairs, may explain effects of hypomagnetic fields on neurogenesis.
- Authors
Ramsay, Jess; Kattnig, Daniel R.
- Abstract
Adult hippocampal neurogenesis and hippocampus-dependent cognition in mice have been found to be adversely affected by hypomagnetic field exposure. The effect concurred with a reduction of reactive oxygen species in the absence of the geomagnetic field. A recent theoretical study suggests a mechanistic interpretation of this phenomenon in the framework of the Radical Pair Mechanism. According to this model, a flavin-superoxide radical pair, born in the singlet spin configuration, undergoes magnetic field-dependent spin dynamics such that the pair's recombination is enhanced as the applied magnetic field is reduced. This model has two ostensible weaknesses: a) the assumption of a singlet initial state is irreconcilable with known reaction pathways generating such radical pairs, and b) the model neglects the swift spin relaxation of free superoxide, which abolishes any magnetic sensitivity in geomagnetic/hypomagnetic fields. We here suggest that a model based on a radical triad and the assumption of a secondary radical scavenging reaction can, in principle, explain the phenomenon without unnatural assumptions, thus providing a coherent explanation of hypomagnetic field effects in biology. Author summary: The hippocampal region of the brain plays a major role in learning and memory functionality. In male mice, shielding of the Earth's magnetic field was found to decrease hippocampal neurogenesis, i.e. the formation of new neurons, following from a decrease in levels of reactive oxygen species. In this study, we suggest an explanation in terms of spin dynamics of a three radical system composed of flavin-semiquinone, superoxide and ascorbyl radical. This model agrees with the experimental data whilst retaining realistic parameters for a biological system, unlike the Radical Pair Mechanism.
- Subjects
DEVELOPMENTAL neurobiology; INDUCTIVE effect; GEOMAGNETISM; NEUROGENESIS; REACTIVE oxygen species; BIOLOGICAL systems
- Publication
PLoS Computational Biology, 2022, Vol 18, Issue 9, p1
- ISSN
1553-734X
- Publication type
Article
- DOI
10.1371/journal.pcbi.1010519