We found a match
Your institution may have access to this item. Find your institution then sign in to continue.
- Title
Copper(II)-Catalyzed Aerobic Oxidative Coupling between Chalcone and 2-Aminopyridine via CH Amination: An Expedient Synthesis of 3-Aroylimidazo[1,2- a]pyridines.
- Authors
Monir, Kamarul; Kumar Bagdi, Avik; Mishra, Subhajit; Majee, Adinath; Hajra, Alakananda
- Abstract
A simple and efficient protocol has been developed for the synthesis of 3-aroylimidazopyridines via copper(II) acetate-catalyzed aerobic oxidative amination. A library of 3-aroylimidazopyridines was synthesized from readily accessible chalcones and 2-aminopyridines with high yields and regioselectivity. The reaction proceeds through a tandem Michael addition followed by an intramolecular oxidative amination. The successful application of this methodology for a gram-scale reaction indicates its potential for bulk synthesis.
- Subjects
OXIDATIVE coupling; CHALCONES; AMINATION; HETEROCYCLIC compounds; CHEMICAL reactions
- Publication
Advanced Synthesis & Catalysis, 2014, Vol 356, Issue 5, p1105
- ISSN
1615-4150
- Publication type
Other
- DOI
10.1002/adsc.201300900