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- Title
Epidermal growth factor receptor (EGFR) amplification rates observed in screening patients for randomized trials in glioblastoma.
- Authors
Lassman, Andrew B.; Aldape, Kenneth D.; Ansell, Peter J.; Bain, Earle; Curran, Walter J.; Eoli, Marica; French, Pim J.; Kinoshita, Manabu; Looman, Jim; Mehta, Minesh; Muragaki, Yoshihiro; Narita, Yoshitaka; Ocampo, Christopher; Roberts-Rapp, Lisa; Song, Minghao; Vogelbaum, Michael A.; Walenkamp, Annemiek M. E.; Wang, Tony J. C.; Zhang, Peixin; van den Bent, Martin J.
- Abstract
Purpose: Epidermal growth factor receptor (EGFR) amplification has been reported to occur in ~ 50% of glioblastomas (GBMs). We are conducting several global studies that require central testing for EGFR amplification during screening, representing an opportunity to confirm the frequency of amplification in GBM in a large cohort and to evaluate whether EGFR amplification differs by region of the world. Methods: EGFR amplification was measured by fluorescence in situ hybridization during screening for therapeutic trials of an EGFR antibody–drug conjugate: two Phase 2/3 global trials (INTELLANCE-1, INTELLANCE-2), and a Japanese Phase 1/2 trial (INTELLANCE-J). We evaluated the proportion of tumor tissue samples harboring EGFR amplification among those tested and differences in amplification frequency by geography. Results: EGFR was amplified in 54% of 3150 informative cases screened for INTELLANCE-1 and -2, consistent with historic controls, but was significantly lower in patients from Asia versus the rest of the world (35% vs. 56%, P < 0.0030). The independent INTELLANCE-J trial validated this finding (33% amplified of 153 informative cases). Conclusions: EGFR amplification occurs less frequently in patients from Asia than elsewhere. Further study is required to understand biological differences to optimize treatment in glioblastoma.
- Subjects
ASIA; EPIDERMAL growth factor receptors; FLUORESCENCE in situ hybridization; ANTIBODY-drug conjugates
- Publication
Journal of Neuro-Oncology, 2019, Vol 144, Issue 1, p205
- ISSN
0167-594X
- Publication type
Article
- DOI
10.1007/s11060-019-03222-y