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- Title
Cross-relaxation imaging of human articular cartilage.
- Authors
Stikov, Nikola; Keenan, Kathryn E.; Pauly, John M.; Smith, R. Lane; Dougherty, Robert F.; Gold, Garry E.
- Abstract
In this article, cross-relaxation imaging is applied to human ex vivo knee cartilage, and correlations of the cross-relaxation imaging parameters with macromolecular content in articular cartilage are reported. We show that, unlike the more commonly used magnetization transfer ratio, the bound pool fraction, the cross-relaxation rate ( k) and the longitudinal relaxation time ( T1) vary with depth and can therefore provide insight into the differences between the top and bottom layers of articular cartilage. Our cross-relaxation imaging model is more sensitive to macromolecular content in the top layers of cartilage, with bound pool fraction showing moderate correlations with proteoglycan content, and k and T1 exhibiting moderate correlations with collagen. Magn Reson Med, 2011. © 2011 Wiley-Liss, Inc.
- Publication
Magnetic Resonance in Medicine, 2011, Vol 66, Issue 3, p725
- ISSN
0740-3194
- Publication type
Article
- DOI
10.1002/mrm.22865