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- Title
Comparative MR study of hepatic fat quantification using single-voxel proton spectroscopy, two-point dixon and three-point IDEAL.
- Authors
Kim, Hyeonjin; Taksali, Sara E.; Dufour, Sylvie; Befroy, Douglas; Goodman, T. Robin; Petersen, Kitt Falk; Shulman, Gerald I.; Caprio, Sonia; Constable, R. Todd
- Abstract
Hepatic fat fraction (HFF) was measured in 28 lean/obese humans by single-voxel proton spectroscopy (MRS), a two-point Dixon (2PD), and a three-point iterative decomposition of water and fat with echo asymmetry and least-squares estimation (IDEAL) method (3PI). For the lean, obese, and total subject groups, the range of HFF measured by MRS was 0.3-3.5% (1.1 ± 1.4%), 0.3-41.5% (11.7 ± 12.1), and 0.3-41.5% (10.1 ± 11.6%), respectively. For the same groups, the HFF measured by 2PD was −6.3-2.2% (−2.0 ± 3.7%), −2.4-42.9% (12.9 ± 13.8%), and −6.3-42.9% (10.5 ± 13.7%), respectively, and for 3PI they were 7.9-12.8% (10.1 ± 2.0%), 11.1-49.3% (22.0 ± 12.2%), and 7.9-49.3% (20.0 ± 11.8%), respectively. The HFF measured by MRS was highly correlated with those measured by 2PD ( r = 0.954, P < 0.001) and 3PI ( r = 0.973, P < 0.001). With the MRS data as a reference, the percentages of correct differentiation between normal and fatty liver with the MRI methods ranged from 68-93% for 2PD and 64-89% for 3PI. Our study demonstrates that the apparent HFF measured by the MRI methods can significantly vary depending on the choice of water-fat separation methods and sequences. Such variability may limit the clinical application of the MRI methods, particularly when a diagnosis of early fatty liver needs to be performed. Therefore, protocol-specific establishment of cutoffs for liver fat content may be necessary. Magn Reson Med 59:521-527, 2008. © 2008 Wiley-Liss, Inc.
- Publication
Magnetic Resonance in Medicine, 2008, Vol 59, Issue 3, p521
- ISSN
0740-3194
- Publication type
Article
- DOI
10.1002/mrm.21561