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- Title
Heat treatment increases the incidence of alopecia areata in the C3H/HeJ mouse model.
- Authors
Wikramanayake, Tongyu; Alvarez-Connelly, Elizabeth; Simon, Jessica; Mauro, Lucia; Guzman, Javier; Elgart, George; Schachner, Lawrence; Chen, Juan; Plano, Lisa; Jimenez, Joaquin
- Abstract
lopecia areata (AA) is a common autoimmune disease characterized by non-scarring hair loss. Previous studies have demonstrated an association between AA and physiological/psychological stress. In this study, we investigated the effects of heat treatment, a physiological stress, on AA development in C3H/HeJ mice. Whereas this strain of mice are predisposed to AA at low incidence by 18 months of age, we observed a significant increase in the incidence of hair loss in heat-treated 8-month-old C3H/HeJ mice compared with sham-treated mice. Histological analysis detected mononuclear cell infiltration in anagen hair follicles, a characteristic of AA, in heat-treated mouse skin. As expected, increased expression of induced HSPA1A/B (formerly called HSP70i) was detected in skin samples from heat-treated mice. Importantly, increased HSPA1A/B expression was also detected in skin samples from C3H/HeJ mice that developed AA spontaneously. Our results suggest that induction of HSPA1A/B may precipitate the development of AA in C3H/HeJ mice. For future studies, the C3H/HeJ mice with heat treatment may prove a useful model to investigate stress response in AA.
- Subjects
ALOPECIA areata; AUTOIMMUNE diseases; HEAT shock proteins; LABORATORY mice; PHYSIOLOGICAL stress; PSYCHOLOGICAL stress; HISTOLOGY
- Publication
Cell Stress & Chaperones, 2010, Vol 15, Issue 6, p985
- ISSN
1355-8145
- Publication type
Article
- DOI
10.1007/s12192-010-0209-7