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- Title
Use of laser flare-cell photometry to quantify intraocular inflammation in patients with Behçet Uveitis.
- Authors
Kürsat Cingü; Nur Kir; Baris Yeniad; Meri Urgancioglu; Ahmet Gül
- Abstract
Abstract Purpose To assess the usefulness of laser flare-cell photometry to quantify intraocular inflammation in patients with Behçet disease. Methods The study comprised 47 healthy individuals, 78 Behçet patients without ocular involvement, 54 Behçet patients with a uveitis attack and 53 Behçet patients with uveitis in clinical remission. A single observer assigned clinical scores to anterior chamber cells, vitreous haze, and fundus lesions in the attack group. Laser flare-cell photometry measurements were performed by another observer who was masked to the clinical findings. Fundus fluorescein angiography was performed only in the remission group, and fluorescein leakage was scored by a masked retina specialist. The risk of recurrent uveitis attack was analyzed in eyes with high versus low flare values in the remission group. Main outcome measures were anterior chamber flare in Behçet patients compared to the control group, and correlations of flare with clinical scores of intraocular inflammation and with fluorescein leakage. Mann-Whitney U-test, Spearman’s bivariate correlation test, linear regression method, and Kaplan-Meier method were used for statistical analyses. Results Mean flare was not increased in Behçet patients without ocular involvement. It was significantly higher in patients with Behçet uveitis both during attacks and in remission (P 6 photons/msec than in eyes with flare values ≤6 photons/msec (right eyes, P P = 0.0184). Conclusions Laser flare-cell photometry is a useful objective method in the quantitative assessment of intraocular inflammation in patients with Behçet uveitis. The use of this quantitative technique in clinical trials of Behçet uveitis may provide comparable data, as it gives an objective measure of intraocular inflammation. In clinical practice, it may reduce the need for fluorescein angiography because it seems to be especially useful in monitoring persistent retinal vascular leakage in patients who are clinically in remission.
- Subjects
EYE inflammation; EYE diseases; INFLAMMATION; DISEASE remission
- Publication
Graefe's Archive of Clinical & Experimental Ophthalmology, 2008, Vol 246, Issue 8, p1169
- ISSN
0721-832X
- Publication type
Article