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- Title
Moderate exercise training decreases aortic superoxide production in myocardial infarcted rats.
- Authors
Zanchi, Nelo Eidy; Bechara, Luiz Roberto Grassmann; Tanaka, Leonardo Yuji; Debbas, Victor; Bartholomeu, Teresa; Ramires, Paulo Rizzo
- Abstract
Myocardial infarction (MI) has been associated with increases in reactive oxygen species (ROS). Exercise training (ET) has been shown to exert positive modulations on vascular function and the purpose of the present study was to investigate the effect of moderate ET on the aortic superoxide production index, NAD(P)H oxidase activity, superoxide dismutase activity and vasomotor response in MI rats. Aerobic ET was performed during 11 weeks. Myocardial infarction significantly diminished maximal exercise capacity, and increased vasoconstrictory response to norepinephrine, which was related to the increased activity of NAD(P)H oxidase and basal superoxide production. On the other hand, ET normalized the superoxide production mostly due to decreased NAD(P)H oxidase activity, although a minor SOD effect may also be present. These adaptations were paralleled by normalization in the vasoconstrictory response to norepinephrine. Thus, diminished ROS production seems to be an important mechanism by which ET mediates its beneficial vascular effects in the MI condition.
- Subjects
MYOCARDIAL infarction; SUPEROXIDE dismutase; EXERCISE physiology; REACTIVE oxygen species; VASCULAR resistance; ANIMAL experimentation; BIOLOGICAL models; VASODILATION; ENDOTHELIUM; NORADRENALINE; OXIDOREDUCTASES; PEROXIDES; PHYSICAL fitness; RATS; VASOCONSTRICTORS; VASOCONSTRICTION; THORACIC aorta; PHARMACODYNAMICS
- Publication
European Journal of Applied Physiology, 2008, Vol 104, Issue 6, p1045
- ISSN
1439-6319
- Publication type
journal article
- DOI
10.1007/s00421-008-0861-0