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- Title
Spatial immune profiling of glioblastoma identifies an inflammatory, perivascular phenotype associated with longer survival.
- Authors
Wirsching, Hans-Georg; Felsberg, Jörg; Prummer, Michael; Moisoiu, Vlad; Lourman, Roxanne; Hertler, Caroline; Antonios, Michelle; Cimino, Patrick J.; Roth, Patrick; Gorlia, Thierry; Prins, Robert M.; Cloughesy, Timothy; Wen, Patrick Y.; Holland, Eric C.; Reifenberger, Guido; Weller, Michael
- Abstract
First, we analyzed 360 anatomically defined glioblastoma regions of interest by spatial immune profiling utilizing a panel of 28 DNA bar-coded antibodies to quantify immune cell types and immunotherapy targets in perivascular, perinecrotic and cell-dense tumor regions (Fig. Prominent and disease-defining histopathologic features of glioblastoma, the most common type of glioma, include microvascular proliferation and necrosis, the latter often with perinecrotic palisading of tumor cells [[3]].
- Subjects
GENE expression profiling; GLIOBLASTOMA multiforme; CENTRAL nervous system tumors; TRANSFORMING growth factors-beta; PHENOTYPES; IMMUNE checkpoint proteins
- Publication
Acta Neuropathologica, 2023, Vol 146, Issue 4, p647
- ISSN
0001-6322
- Publication type
Article
- DOI
10.1007/s00401-023-02617-6