Glioblastoma (GBM) are aggressive brain tumors that cannot be cured due to genetic and epigenetic heterogeneity and the presence of glioma stem cells [[1], [3]-[5], [7]]. Averaged, log2-transformed, expression of cellular state signature genes in b Microvascular proliferation (MVP). c Infiltrating Tumor (IT); d Leading Edge (LE); e Pseudopallisading cells around necrosis (PAN); and f Cellular Tumor (CT). Brain tumor stem cells: the cancer stem cell hypothesis writ large.