We found a match
Your institution may have access to this item. Find your institution then sign in to continue.
- Title
Expression and immunohistochemical localization of adrenomedullin in the mouse cochlea.
- Authors
Tono, Tetsuya; Shimozono, Masami; Kawano, Hirokazu; Asada, Yujiro; Kitamura, Kazuo; Komune, Shizuo
- Abstract
Adrenomedullin (AM) is a novel hypotensive and vasodilator peptide. It has been shown that AM is biosynthesized in various organs and cells and is suggested to play multiple roles including electrolyte homeostasis and body fluid control. The present study describes for the first time the presence of mRNA for AM and AM-like immunoreactivity in the cochlea. A reverse transcription-polymerase chain reaction (RT-PCR) performed with gene-specific AM primer on total RNA extracted from mouse cochlea revealed a PCR product of the expected size. Immunohistochemical examination showed positive immunostaining in vascular smooth muscle cells of the modiolar arterioles and in the stria vascularis of the cochlea. These results suggest that AM may play a role in the regulation not only of cochlear hemodynamics but also of cochlear fluid dynamics.
- Publication
ORL, 2002, Vol 64, Issue 3, p169
- ISSN
0301-1569
- Publication type
journal article
- DOI
10.1159/000058020