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- Title
Unlocking the molecular secrets of sodium-coupled transporters.
- Authors
Krishnamurthy, Harini; Piscitelli, Chayne L.; Gouaux, Eric
- Abstract
Transmembrane sodium-ion gradients provide energy that can be harnessed by 'secondary transporters' to drive the translocation of solute molecules into a cell. Decades of study have shown that such sodium-coupled transporters are involved in many physiological processes, making them targets for the treatment of numerous diseases. Within the past year, crystal structures of several sodium-coupled transporters from different families have been reported, showing a remarkable structural conservation between functionally unrelated transporters. These atomic-resolution structures are revealing the mechanism of the sodium-coupled transport of solutes across cellular membranes.
- Subjects
CELL communication; CELLULAR control mechanisms; CHROMOSOMAL translocation; CYTOLOGICAL research; PHYSIOLOGIC salines; BIOCHEMISTRY
- Publication
Nature, 2009, Vol 459, Issue 7245, p347
- ISSN
0028-0836
- Publication type
Article
- DOI
10.1038/nature08143