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- Title
A feasibility study of novel ultrasonic tissue characterization for prostate-cancer diagnosis: 2D spectrum analysis of in vivo data with histology as gold standard.
- Authors
Tian Liu; Mansukhani, Mahesh M.; Benson, Mitchell C.; Ennis, Ronald; Yoshida, Emi; Schiff, Peter B.; Pengpeng Zhang; Jun Zhou; Kutcher, Gerald J.
- Abstract
This study demonstrates the feasibility of using a novel 2D spectrum ultrasonic tissue characterization (UTC) technique for prostate-cancer diagnosis. Normalized 2D spectra are computed by performing Fourier transforms along the range (beam) and the cross-range directions of the digital radio-frequency echo data, then dividing by a reference spectrum. This 2D spectrum method provides axial and lateral information of tissue microstructures, an improvement over the current 1D spectrum analysis which only provides axial information. A pilot study was conducted on four prostate-cancer patients who underwent radical prostatectomies. Cancerous and noncancerous regions of interest, identified through histology, were compared using four 2D spectral parameters: peak value and 3 dB width of the radially integrated spectral power (RISP), slope and intercept of the angularly integrated spectral power (AISP). For noncancerous and cancerous prostatic tissues, respectively, our investigation yielded 23±1 and 26±1 dB for peak value of RISP, 7.8±0.5° and 7.6±0.6° for 3 dB of RISP, -2.1±0.2 and -2.7±0.4 dB/MHz for slope of AISP, and 92±5 and 112±6 dB for intercept of AISP. Preliminary results indicated that 2D spectral UTC has the potential for identifying tumor-bearing regions within the prostate gland.
- Subjects
DIAGNOSTIC ultrasonic imaging; PROSTATE cancer; HISTOLOGY; MICROSTRUCTURE; MEDICAL physics
- Publication
Medical Physics, 2009, Vol 36, Issue 8, p3504
- ISSN
0094-2405
- Publication type
Article
- DOI
10.1118/1.3166360