We found a match
Your institution may have access to this item. Find your institution then sign in to continue.
- Title
Free radical scavengers, anti-inflammatory and analgesic activity of Acaena magellanica.
- Authors
Feresin, Gabriela Egly; Tapia, Alejandro; Angel, Gutierrez R.; Delporte, Carla; Erazo, Nadine Backhouse; Schmeda-Hirschmann, Guillermo
- Abstract
Extracts of the whole plant Acaena magellanica (Rosaceae) were assessed for anti-inflammatory, antipyretic and analgesic activity in animal models. At 600 mg kg−1, the global ethanolic extract (GEE), dichloromethane (DCM) and defatted methanol (MeOH) fractions showed a mild anti-inflammatory effect in the carrageenan-induced guinea-pig paw oedema. The GEE, DCM and defatted MeOH fractions significantly reduced inflammation by 43.2, 40.5 and 42.1%, respectively. The GEE did not showed any significant antipyretic activity in doses up to 600 mg kg−1. A 20% w/v infusion administered orally at 16 mL kg−1 presented analgesic effect in the acetic acid-induced abdominal constriction test in mice. The GEE and MeOH extract of A. magellanica showed free radical scavenging activity in the diphenylpicrylhydrazyl decolouration assay. Assay-guided isolation led to quercetin, Q-3- O-β-D-glucoside, Q-3- O-β-D-galactoside, ellagic acid and catechin as the free radical scavengers. The saponins tormentic acid 28- O-β-D-galactopyranoside and 28- O-β-D-glucopyranoside were isolated from the polar extract. The structures were determined by spectroscopic methods.
- Publication
Journal of Pharmacy & Pharmacology, 2002, Vol 54, Issue 6, p835
- ISSN
0022-3573
- Publication type
Article
- DOI
10.1211/0022357021779014