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- Title
Biochemical Effects and Early Lesions in Regard to Dose-Response Studies.
- Authors
Neumann, Hans-Günter
- Abstract
Trans-4-dimethylaminostilbene is metabolically activated independent of dose after single doses ranging from 5xl0-10 up to the LD50 = 2.5x10-4 mol/kg. This is based on the dose related increase of covalent binding to macromolecules in liver, blood and kidney 24 h after oral administration to female Wistar rats. Deviations from proportionality at high doses are related to the rate rather than to the extent of formation of altered cell constituents. It is concluded that the early biochemical lesions critical to tumor formation are also independent of dose. A pharmacokinetic threshold with subcarcinogenic doses cannot be demonstrated down to exposures equivalent to 25 ng per animal or 2 μg/kg diet. Copyright © 1980 S. Karger AG, Basel
- Publication
Oncology, 1980, Vol 37, Issue 4, p255
- ISSN
0030-2414
- Publication type
Article
- DOI
10.1159/000225447