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- Title
Thread-Induced Epidermization in the Uterine Horn of Mice, and the Influence of 20-Methylcholanthrene.
- Authors
Graham, C.E.
- Abstract
Four weeks after implantation of plain, beeswax impregnated, or 20-methylcholanthrene-beeswax impregnated threads into the uterine and cervical canal of mice, there was a cranial displacement of the cervical squamocolumnar junction, resulting from the formation of new stratified squamous epithelium. The newly formed stratified epithelium was always continuous with the pre-existing cervical stratified squamous epithelium, and arose, by extension from it. This conclusion mostly depends on the absence of intermediate types of epithelium showing evidence of undergoing metaplastic transformation from columnar into stratified epithelium, and is further supported by the finding that if the thread was placed high in the uterus so that it was not in contact with the cervical stratified epithelium, no new stratified epithelium was formed. Cervical squamous carcinomas induced by methylcholanthrene impregnated threads, even those located above the original squamocolumnar junction, could arise from the original cervical stratified epithelium, directly or indirectly, rather than by metaplasia of columnar cells. Copyright © 1971 S. Karger AG, Basel
- Publication
Oncology, 1971, Vol 25, Issue 1, p83
- ISSN
0030-2414
- Publication type
Article
- DOI
10.1159/000224558