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- Title
Primary dendrites of mitral cells synapse unto neighboring glomeruli independent of their odorant receptor identity.
- Authors
Nishizumi, Hirofumi; Miyashita, Akihiro; Inoue, Nobuko; Inokuchi, Kasumi; Aoki, Mari; Sakano, Hitoshi
- Abstract
In the mouse olfactory bulb, neural map topography is largely established by axon–axon interactions of olfactory sensory neurons (OSNs). However, to make the map functional, the OSNs must make proper connections to second-order neurons, the mitral cells. How do the mitral-cell dendrites find their partner glomeruli for synapse formation with OSN axons? Here, we analyze dendrite connections of mitral cells in various mutant mice in which glomerular formation is perturbed. Our present results support the proximity model, whereby mitral cells tend to connect primary dendrites to the nearest neighboring glomeruli regardless of their odorant receptor identities. The physical location of glomeruli rather than the odorant-receptor specificity appears to play a key role in matching mitral cells with their partner OSN axons. Hirofumi Nishizumi et al. examined dendrite connections in olfactory bulb mitral cells of mice with perturbed glomerular formation. Their findings support the model that mitral cells connect primary dendrites to neighboring glomeruli.
- Subjects
KIDNEY glomerulus; AXONS; OLFACTORY receptors; NEURONS; DENDRITES
- Publication
Communications Biology, 2019, Vol 2, Issue 1, pN.PAG
- ISSN
2399-3642
- Publication type
Article
- DOI
10.1038/s42003-018-0252-y