We found a match
Your institution may have access to this item. Find your institution then sign in to continue.
- Title
The impact of intraperitoneal antibiotic administration in patients with peritoneal dialysis-related peritonitis: systematic review and meta-analysis.
- Authors
Morimoto, Kohkichi; Terawaki, Hiroyuki; Washida, Naoki; Kasai, Takahiro; Tsujimoto, Yasushi; Yuasa, Hidemichi; Ryuzaki, Munekazu; Ito, Yasuhiko; Tomo, Masashi; Nakamoto, Hidetomo
- Abstract
Background: Peritonitis is a common and clinically important complication in patients receiving peritoneal dialysis (PD). Antibiotic administration is essential for PD-related peritonitis, but routes of administration have not been established enough. Here, we performed a systematic review to assess the efficacy and safety of intraperitoneal (IP) antibiotic administration compared to intravenous (IV) antibiotic administration in patients with PD-related peritonitis. Methods: Cochrane CENTRAL, MEDLINE, and Ichushi-Web were searched in June 2017. Preferred Reporting Items for Systematic Reviews and Meta-Analysis (PRISMA) guidelines were followed, and articles were screened by four independent reviewers. Results: Two randomized controlled trials (113 patients) were identified. IP antibiotic administration was more effective than IV antibiotic administration. The pooled risk difference between IP and IV was 0.13 (95% CI − 0.17 to 0.43). Safety assessment indicated less frequency of side effects in patients receiving IP antibiotic administration. The pooled risk ratios of IV to IP regarding adverse drug reaction-related and administration route-related side effects were 5.13 (0.63 to 41.59) and 3.00 (0.14 to 65.90), respectively. Conclusion: The systematic review and meta-analysis suggested that IP antibiotic administration is more effective and safer in patients with PD-related peritonitis compared to IV antibiotic administration.
- Subjects
ANTIBIOTICS; MEDICAL databases; ONLINE information services; PERITONITIS; INTRAVENOUS therapy; META-analysis; CONFIDENCE intervals; SYSTEMATIC reviews; INTRAPERITONEAL injections; PERITONEAL dialysis; TREATMENT effectiveness; COMPARATIVE studies; MEDLINE; DATA analysis software; EVALUATION
- Publication
Renal Replacement Therapy, 2020, Vol 6, Issue 1, p1
- ISSN
2059-1381
- Publication type
Article
- DOI
10.1186/s41100-020-00270-3