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- Title
Introducing the next generation.
- Authors
Kritikou, Ekat
- Abstract
The article reports on the study conducted which presents the second generation of induced pluripotent stem cells (iPS cells), the transcription factors in mouse fibroblasts. The inquiry was done through the stringent selection strategy for the isolation of iPS cells. The data gathered in the investigation revealed that transcription-induced reprogramming leads to global reversion of the somatic epigenome into an embryonic stem-cell-like state.
- Subjects
TRANSCRIPTION factors; CONNECTIVE tissue cells; EMBRYONIC stem cells; EMBRYOLOGY; CHROMOSOMES; GENETICS; CELL nuclei
- Publication
Nature Reviews Molecular Cell Biology, 2007, Vol 8, Issue 7, p512
- ISSN
1471-0072
- Publication type
Article
- DOI
10.1038/nrm2211