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- Title
Mutaciones genéticas que confieren resistencia a Isoniacida en pacientes con tuberculosis en Lima Centro, Perú 2017-2018.
- Authors
Vargas-Ponce, Kenneth G.; Trujillo-Valencia, Claudia L.; Saravia-Ruiz, Trilce; Salas-López, Juan A.; Llanos-Tejada, Félix K.
- Abstract
This a report of the frequency of KatG and inhA genetic mutations that confer resistance to isoniazid in a sample of 777 patients with resistance to isoniazid. GenoType® MTBDRplus test and conventional sensitivity tests by the agar plate method were used. It was found that 54% presented mutation in the KatG gene, associated with higher resistance to streptomycin 76.6% (p <0.05), rifampicin 66.7% (p <0.05) and ethionamide in 33% (p <0.05). inhA gene mutation has a frequency of 46% and was associated with resistance to ethionamide in 68.1% (p <0.05), rifampicin 47.2% (p <0.05) and streptomycin 33% (p <0.05). In this sample, the presences of mutations that confer resistance to isoniazid was associated with resistance to other antituberculosis drugs.
- Publication
Acta Médica Peruana, 2021, Vol 38, Issue 2, p151
- ISSN
1018-8800
- Publication type
Article
- DOI
10.35663/amp.2021.382.1892