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- Title
ABC transporters: the power to change.
- Authors
Rees, Douglas C.; Johnson, Eric; Lewinson, Oded
- Abstract
ATP-binding cassette (ABC) transporters constitute a ubiquitous superfamily of integral membrane proteins that are responsible for the ATP-powered translocation of many substrates across membranes. The highly conserved ABC domains of ABC transporters provide the nucleotide-dependent engine that drives transport. By contrast, the transmembrane domains that create the translocation pathway are more variable. Recent structural advances with prokaryotic ABC transporters have provided a qualitative molecular framework for deciphering the transport cycle. An important goal is to develop quantitative models that detail the kinetic and molecular mechanisms by which ABC transporters couple the binding and hydrolysis of ATP to substrate translocation.
- Subjects
ATP-binding cassette transporters; CHROMOSOMAL translocation; PROKARYOTES; HYDROLYSIS; HOMEOSTASIS
- Publication
Nature Reviews Molecular Cell Biology, 2009, Vol 10, Issue 3, p218
- ISSN
1471-0072
- Publication type
Article
- DOI
10.1038/nrm2646