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- Title
Cis-acting effect of the IL1B C-31T polymorphism on IL-1ßmRNA expression.
- Authors
Kimura, R.; Nishioka, T.; Soemantri, A.; Ishida, T.
- Abstract
Since the effect of IL1B polymorphisms on IL-1ßproduction is still controversial, we selected two polymorphisms to test their cis-acting effect on IL-1ßmRNA expression by means of the allele-specific transcript quantification and the haplotype analysis. As for the C-31T polymorphism, we found that expression of the-31T allele was 2.2 times of the-31C allele. This higher transcription efficiency may correspond to the fact that C-31T is located in a TATA box. The other polymorphism, C+3954T, did not alter the levels of transcription. The use of the allele-specific transcript quantification enables us to exclude trans-acting effects of polymorphisms on the gene expression and contributes to understanding the roles of the IL1B polymorphisms in susceptibility to multifactorial diseases.Genes and Immunity (2004) 5, 572-575. doi:10.1038/sj.gene.6364128 Published online 9 September 2004
- Subjects
GENETIC polymorphisms; INTERLEUKINS; CYTOKINES; MESSENGER RNA; GENETIC transcription; GENE expression
- Publication
Genes & Immunity, 2004, Vol 5, Issue 7, p572
- ISSN
1466-4879
- Publication type
Article
- DOI
10.1038/sj.gene.6364128