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- Title
Transplanted human multipotent stromal cells reduce acute tongue fibrosis in rats.
- Authors
Vahabzadeh‐Hagh, Andrew M.; Goel, Alexander N.; Frederick, John W.; Berke, Gerald S.; Long, Jennifer L.
- Abstract
Background: Tongue fibrosis resulting from head and neck cancer, surgery, radiation, chemotherapy, or a combination thereof devastates one's quality of life. Therapeutic options are limited. Here we investigate human bone marrow–derived multipotent stromal cells (MSC) as a novel injectable treatment for post‐injury tongue fibrosis. Methods: MSCs were grown in culture. Eighteen athymic rats underwent unilateral partial glossectomy. After two weeks for scar formation, a single injection was performed in the tongue scar. Three treatment groups were studied: low and high concentration MSC, and control media injection. Tongues were harvested for evaluation at three weeks post‐treatment. Results: Dense fibrosis was achieved in control animals at five weeks. High concentration MSC reduced cross sectional scar burden (P =.007) and pathologic score for inflammation and fibrosis. Conclusion: This study establishes the feasibility of a novel rodent tongue fibrosis model, and begins to assess the utility of human MSCs to reduce scar burden. Level of Evidence: N/a A Special Visual Abstract has been developed for this paper. (Visual Abstract 1)
- Subjects
HEAD &; neck cancer; MESENCHYMAL stem cells; SQUAMOUS cell carcinoma; BONE marrow; STROMAL cells
- Publication
Laryngoscope Investigative Otolaryngology, 2018, Vol 3, Issue 6, p450
- ISSN
2378-8038
- Publication type
Article
- DOI
10.1002/lio2.202