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- Title
Schizophrenia and anti-toxoplasmosis antibody carriership.
- Authors
Stoimenova-Popova, M.; Veleva, I.; Lalev, M.; Angelov, I.; Chumpalova, P.; Tumbev, L.; Todorov, A.; Valkova, M.
- Abstract
Introduction: Recent investigations have demonstrated both congenital and acquired forms of toxoplasmosis lead to changes in behavior and psychomotor skills, similar to those seen in schizophrenia. Objectives: To seek a possible relationship between the infection with T. gondii and the severity of schizophrenia. Methods: We examined 108 patients with schizophrenia and 108 control subjects. An immunoenzyme method (ELISA) was used to investigate a potential presence of anti-toxoplasmosis IgG and IgM. Patients with schizophrenia were additionally examined via Positive and Negative Syndrome Scale (PANSS). Results: The analyze revealed a statistically significant higher frequency of carriership of anti-toxoplasmosis IgG in the patients with schizophrenia, as compared with the controls, p=0.01. The presence of high levels of anti-toxoplasmosis IgG antibodies was found in 69.23% of patients with schizophrenia and in 56.10% of mentally healthy subjects. The difference in concentrations of anti-toxoplasmosis IgG in both groups was not statistically reliable (p > 0.05). Conclusions: Our investigation of positive and negative syndromes did not reveal statistically significant differences between the patients with schizophrenia IgG carriers those with negative serological test results. A statistically reliable difference was found by comparing the results from evaluation of the symptoms of disorganization (p = 0.01). Sex, age and education did not influence the ability to carry anti-toxoplasmosis antibodies in patients with.
- Subjects
IMMUNOGLOBULINS; PEOPLE with schizophrenia; SCHIZOPHRENIA; IMMUNOGLOBULIN G; TOXOPLASMOSIS; 22Q11 deletion syndrome
- Publication
European Psychiatry, 2020, Vol 63, pS253
- ISSN
0924-9338
- Publication type
Article