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- Title
The MINDVIEW project: First results.
- Authors
Benlloch, José M.; González, Antonio J.; Pani, Roberto; Preziosi, Enrico; Jackson, Carl; Murphy, John; Barberá, Julio; Correcher, Carlos; Aussenhofer, Sebastian; Gareis, Daniel; Visvikis, Dimitris; Bert, Julien; Langstrom, Bengt; Farde, Lars; Toth, Miklos; Haggkvist, Jenny; Caixeta, Fabio V.; Kullander, Klas; Somlai-Schweiger, Ian; Schwaiger, Markus
- Abstract
We present the first results of the MINDVIEW project. An innovative imaging system for the human brain examination, allowing simultaneous acquisition of PET/MRI images, has been designed and constructed. It consists of a high sensitivity and high resolution PET scanner integrated in a novel, head-dedicated, radio frequency coil for a 3T MRI scanner. Preliminary measurements from the PET scanner show sensitivity 3 times higher than state-of-the-art PET systems that will allow safe repeated studies on the same patient. The achieved spatial resolution, close to 1 mm, will enable differentiation of relevant brain structures for schizophrenia. A cost-effective and simple method of radiopharmaceutical production from 11 C-carbon monoxide and a mini-clean room has been demonstrated. It has been shown that 11 C-raclopride has higher binding potential in a new VAAT null mutant mouse model of schizophrenia compared to wild type control animals. A significant reduction in TSPO binding has been found in gray matter in a small sample of drug-naïve, first episode psychosis patients, suggesting a reduced number or an altered function of immune cells in brain at early stage schizophrenia.
- Subjects
BRAIN imaging; MAGNETIC resonance imaging; RADIO frequency; SCHIZOPHRENIA; PSYCHOSES
- Publication
European Psychiatry, 2018, Vol 50, p21
- ISSN
0924-9338
- Publication type
Article
- DOI
10.1016/j.eurpsy.2018.01.002