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- Title
The Diagnostic Value of Acute Phase Proteins in Barki Ewes with Pregnancy Toxemia.
- Authors
Darwish, Asmaa A.; El Ebissy, Iman A.
- Abstract
Pregnancy toxemia is a fatal metabolic disease resulting in high mortalities in late pregnant ewes. The silent nature of the disease and lack of diagnostic tools decrease the chance of prediction and curing. In this paper, we tried to find out the benefits of APPs, cytokines, and iron profile in diagnosis and prediction of the disease and their relation with other disease metabolic changes. Blood samples were collected from sixty barki ewes housed in Matrouh Research Station and were divided into 3 groups;control, healthy late pregnant, and pregnant toxemic group. Biochemical analysis such as BHB, NEFA, Fb, Cp, Hp, SAA, Tf, ferritin concentrations, cytokines (IL-1α, IL-1β, IL-6, IL-10, TNF-α) were measured and all the data were analyzed statically. The results confirmed that APPs and cytokines are valuable markers for pregnancy toxemia as they have a sensitivity and NPV as 100% and high values of specificity, LR, PPV and accuracy rate. But APPs had higher percentages of increase than cytokines, especially Hp. Moreover, both of APPs and cytokines correlate well with the other metabolic changes of the disease. Regarding the iron status, there was a significant decrease in mean concentrations of serum iron, ferritin, Tf sat. % and a significant elevation in TIBC, UBIC and serum transferrin concentrations in the late pregnant ewes in comparison to the control healthy group. On the other hand, the pregnancy toxemic ewes demonstrated a significant rise in the mean concentrations of serum iron, ferritin, Tfsat. % and a significant drop in TIBC, UBIC and serum transferrin concentrations relative to the late pregnant group.
- Subjects
ACUTE phase proteins; PREECLAMPSIA; FERRITIN; EWES; METABOLIC disorders
- Publication
Alexandria Journal of Veterinary Sciences, 2019, Vol 62, Issue 1, p27
- ISSN
1110-2047
- Publication type
Article
- DOI
10.5455/ajvs.26377