We found a match
Your institution may have access to this item. Find your institution then sign in to continue.
- Title
HBcAb Positivity Increases the Risk of Severe Hepatic Fibrosis Development in HIV/HCV-Positive Subjects From the ICONA Italian Cohort of HIV-Infected Patients.
- Authors
Malagnino, Vincenzo; Cerva, Carlotta; Cingolani, Antonella; Ceccherini-Silberstein, Francesca; Vergori, Alessandra; Cuomo, Gianluca; Perno, Carlo Federico; Puoti, Massimo; Monforte, Antonella d'Arminio; Cozzi-Lepri, Alessandro; Andreoni, Massimo; Sarmati, Loredana; Group, ICONA Foundation Study
- Abstract
Background The aim of this study was to investigate the impact of anti-HBc (HBcAb) positivity on the progression of liver fibrosis (Fibrosis-4 score >3.25) in the Italian cohort of HIV-infected individuals naïve to antiretroviral treatment (ICONA). Methods All patients with FIB-4 <3.25 at baseline were evaluated prospectively: 6966 people with HIV (PWH) were screened and classified based on hepatitis B virus (HBV) and hepatitis C virus (HCV) serology. Results Patients who were HBcAb+/HCV-/HBs antigen (HBsAg)- and HCV+/HBcAb+/HBsAg- or HBsAg+/HBcAb+/HCV- had CD4+ cell counts below the nadir and significantly higher prevalence of AIDS diagnosis at baseline than the other groups (P <.0001). A Cox regression model adjusted for age, HIV transmission mode, country of birth, and alcohol consumption showed a higher relative risk (HR) of progression to FIB-4 >3.25 in HCV+/HBcAb+/HBsAg- patients (HR, 7.2; 95% CI, 3 8–13.64). Conclusions HBcAb+ contributes to liver damage in HIV+/HCV+/HBcAb+/HBsAg- subjects. A careful monitoring for signs of previous HBV infection is needed in this kind of patients.
- Subjects
HEPATIC fibrosis; HIV infection transmission; HIV-positive persons; HEPATITIS C virus; HEPATITIS B virus
- Publication
Open Forum Infectious Diseases, 2021, Vol 8, Issue 1, p1
- ISSN
2328-8957
- Publication type
Article
- DOI
10.1093/ofid/ofaa566