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- Title
血管内皮生长因子受体与肝细胞癌侵袭转移的关系.
- Authors
李存娣; 曹伟娅; 王 健
- Abstract
Vascular endothelial growth factor receptors (VEGFRs)consist of three receptor tyrosine kinase (RTK)superfamily members and two non - RTK superfamily members and bind to the ligand in a non - one - to - one way. VEGFRs mediate various signaling pathways such as Raf1→MAP2K1 /2→ERK1 /2 through cell surface receptor internalization and thus promote the proliferation of hepatocellular carci noma cells,angiogenesis,and lymphangiogenesis. VEGFRs can be highly expressed in local cancerous lesions of liver cancer patients, which is a key factor mediating malignant proliferation,invasion,and metastasis of hepatocellular carcinoma,and the expression of VEGFRs is negatively correlated with progression - free survival. Matrix metalloproteinase -9 and heat shock protein 90β can upregulate VEGFRs to promote the proliferation and metastasis of hepatoma cells,while miR -203a,miR -378a,and miR -199a -3p can downregulate VEGFR expression and inhibit hepatoma cell infiltration. Targeted drug therapy based on VEGFR can induce the apoptosis of hepatoma cells,block tumor angiogenesis,and delay disease progression.
- Publication
Journal of Clinical Hepatology / Linchuang Gandanbing Zazhi, 2019, Vol 35, Issue 7, p1616
- ISSN
1001-5256
- Publication type
Article
- DOI
10.3969/j.issn.1001-5256.2019.07.042