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- Title
Crystal structure of a putative 3‐hydroxypimelyl‐CoA dehydrogenase, Hcd1, from Syntrophus aciditrophicus strain SB at 1.78 Å resolution.
- Authors
Dinh, David M.; Thomas, Leonard M.; Karr, Elizabeth A.
- Abstract
Syntrophus aciditrophicus strain SB is a model syntroph that degrades benzoate and alicyclic acids. The structure of a putative 3‐hydroxypimelyl‐CoA dehydrogenase from S. aciditrophicus strain SB (SaHcd1) was resolved at 1.78 Å resolution. SaHcd1 contains sequence motifs and structural features that belong to the short‐chain dehydrogenase/reductase (SDR) family of NADPH‐dependent oxidoreductases. SaHcd1 is proposed to concomitantly reduce NAD+ or NADP+ to NADH or NADPH, respectively, while converting 3‐hydroxypimelyl‐CoA to 3‐oxopimeyl‐CoA. Further enzymatic studies are needed to confirm the function of SaHcd1.
- Subjects
CRYSTAL structure; NICOTINAMIDE adenine dinucleotide phosphate; NAD (Coenzyme); OXIDOREDUCTASES; SYNTROPHISM
- Publication
Acta Crystallographica: Section F, Structural Biology Communications, 2023, Vol 79, Issue 6, p151
- ISSN
2053-230X
- Publication type
Article
- DOI
10.1107/S2053230X23004399