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- Title
New Role for an Old Protein: An Educational Primer for Use with “The Identification of a Novel Mutant Allele of topoisomerase II in Caenorhabditis elegans Reveals a Unique Role in Chromosome Segregation During Spermatogenesis”.
- Authors
Boateng, Ruby; Allen, Anna K.
- Abstract
Modern experimental techniques, such as whole-genome sequencing and clustered regularly interspaced short palindromic repeats (CRISPR)/Cas9 endogenous genome editing, are enabling researchers to identify and further characterize the roles of proteins that were previously thought of as well defined. In the December 2016 issue of GENETICS, an article by Jaramillo- Lambert et al. identified a new role for the enzyme topoisomerase II in Caenorhabditis elegans male meiosis. This Primer article is designed to provide essential background information on C. elegans spermatogenesis and the relevant scientific techniques that will assist students and instructors in their understanding and discussion of the related article.
- Subjects
CAENORHABDITIS elegans genetics; DNA topoisomerase II; ALLELES; CHROMOSOME segregation; MEIOSIS; OOGENESIS
- Publication
Genetics, 2018, Vol 208, Issue 1, p79
- ISSN
0016-6731
- Publication type
Article
- DOI
10.1534/genetics.117.300482