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- Title
Optically-generated focused ultrasound for noninvasive brain stimulation with ultrahigh precision.
- Authors
Li, Yueming; Jiang, Ying; Lan, Lu; Ge, Xiaowei; Cheng, Ran; Zhan, Yuewei; Chen, Guo; Shi, Linli; Wang, Runyu; Zheng, Nan; Yang, Chen; Cheng, Ji-Xin
- Abstract
High precision neuromodulation is a powerful tool to decipher neurocircuits and treat neurological diseases. Current non-invasive neuromodulation methods offer limited precision at the millimeter level. Here, we report optically-generated focused ultrasound (OFUS) for non-invasive brain stimulation with ultrahigh precision. OFUS is generated by a soft optoacoustic pad (SOAP) fabricated through embedding candle soot nanoparticles in a curved polydimethylsiloxane film. SOAP generates a transcranial ultrasound focus at 15 MHz with an ultrahigh lateral resolution of 83 µm, which is two orders of magnitude smaller than that of conventional transcranial-focused ultrasound (tFUS). Here, we show effective OFUS neurostimulation in vitro with a single ultrasound cycle. We demonstrate submillimeter transcranial stimulation of the mouse motor cortex in vivo. An acoustic energy of 0.6 mJ/cm2, four orders of magnitude less than that of tFUS, is sufficient for successful OFUS neurostimulation. OFUS offers new capabilities for neuroscience studies and disease treatments by delivering a focus with ultrahigh precision non-invasively. We report optically-generated focused ultrasound for non-invasive brain stimulation with ultrahigh precision of 83 µm, which is two orders of magnitude smaller than that of conventional transcranial focused ultrasound.
- Publication
Light: Science & Applications, 2022, Vol 11, Issue 1, p1
- ISSN
2047-7538
- Publication type
Article
- DOI
10.1038/s41377-022-01004-2