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- Title
In vivo assessment of macrophage CNS infiltration during disruption of the blood–brain barrier with focused ultrasound: a magnetic resonance imaging study.
- Authors
Hao-Li Liu; Yau-Yau Wai; Po-Hong Hsu; Lee-Ang Lyu; Jia-Shin Wu; Chia-Rui Shen; Jin-Chung Chen; Tzu-Chen Yen; Jiun-Jie Wang
- Abstract
Focused ultrasound has been discovered to locally and reversibly increase permeability of the blood–brain barrier (BBB). However, inappropriate sonication of the BBB may cause complications, such as hemorrhage and brain tissue damage. Tissue damage may be controlled by selecting optimal sonication parameters. In this study, we sought to investigate the feasibility of labeling cells with superparamagnetic iron oxide particles to assess the inflammatory response during focused-ultrasound-induced BBB opening. We show that infiltration of phagocytes does not occur using optimal parameters of sonication. Taken together, the results of our study support the usefulness and safety of focused-ultrasound-induced BBB opening for enhancing drug delivery to the brain. These findings may have implications for the optimization of sonication parameters.
- Subjects
BLOOD-brain barrier; ULTRASONIC imaging; CEREBRAL hemorrhage; BRAIN damage; ENCEPHALITIS
- Publication
Journal of Cerebral Blood Flow & Metabolism, 2010, Vol 30, Issue 1, p177
- ISSN
0271-678X
- Publication type
Article
- DOI
10.1038/jcbfm.2009.179