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- Title
Effect Of Astaxanthin On Rat Brains Against Oxidative Stress Induced By Cadmium:Biochemical, Histopathological Evaluation.
- Authors
AKKOYUN, Hurrem Turan; BENGÜ, Aydın Şükru; ULUCAN, Aykut; AKKOYUN, Mahire Bayramoğlu; EKİN, Suat; TEMEL, Yusuf; ÇİFTÇİ, Mehmet
- Abstract
Aim of this study is to evaluate protective impact of Astaxanthin (AST) on rats with experimental brain injury induced with Cadmium (Cd). 32 male Wistar albino rats were divided into four groups as Control, Cadmium, Astaxanthin (AST), Cadmium (Cd)+Astaxanthin (AST). Rat brain tissues were obtained at the end of 30th day. Malondialdehyde (MDA), glutathione (GSH) levels and superoxide dismutase (SOD) enzyme activities were measured in brain homogenates and histopathological examination was performed. MDA levels were improvement in cadmium administered group (p<0.01) as well as Cd+AST administered group (p<0.05) compared to control group. In addition a substantial reduction Cd+AST group was observed compared to cadmium administered group (p<0.01). GSH level shows a decrease in Cd and Cd+AST groups compared to control (p<0.05). SOD enzyme activity was found significantly lower in Cd and Cd+AST groups compared to control (p<0.01). In addition, increase of SOD in Cd+AST group compared to cadmium group was also found significant (p<0.05). Histopathological findings in the cerebral cortex and hippocampus were different between groups. In the control and AST administered groups, normal histological structure was observed in the brain, while severe lesions were seen in the Cd administered group and in the Cd+AST group only mild degenerative lesions were observed. As a result, elevated MDA level due to Cd administration was attenuated with AST administration. Decreased GSH level and SOD enzyme activity due to Cd administration was increased with AST administration. In addition, AST administration decreased histopathological lesions. Consequently, it is thought that AST may be used for protection against brain oxidative damage due to Cd.
- Subjects
OXIDATIVE stress; CADMIUM; HISTOPATHOLOGY; ASTAXANTHIN; LABORATORY rats
- Publication
Journal of the Institute of Science & Technology / Iğdır Üniversitesi Fen Bilimleri Enstitüsü Dergisi, 2018, Vol 8, Issue 4, p33
- ISSN
2146-0574
- Publication type
Article
- DOI
10.21597/jist.412070