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- Title
Natural Compounds and Derivatives as New Drug Candidates for Endocrine and Metabolic Disorders: Over One and a Half Decades.
- Authors
Manikkam, Rajalakshmi
- Abstract
Cancer and Diabetes are the leading complex, heterogeneous sets of diseases with higher mortality rates. Phytotherapy emerges as an ultimate treatment strategy because plant-based therapies are highly commendable for their better compatibility, lesser side effects and are also enduring in terms of feasibility and druggability. The endocrine signaling network with receptors and downstream effector molecules are involved in the control mechanisms of homeostasis. The therapeutic potentials of the phytocompounds are therefore interlinked with the cascade of signaling pathways relying on endocrine regulators. Biochemical assays, RIA, cell-based assays such as MTT & LDH, AO/EtBr and DAPI staining, flow cytometric analysis, immunocytochemistry, molecular techniques such as DNA fragmentation using agarose gel electrophoresis, gene and protein expression studies via PCR and Western blot techniques, Light microscopic studies and immunohistochemical analysis of tissues, CADD and molecular docking analysis were applied to fulfill the objectives. The antidiabetic, anticancer and chemopreventive efficacy of the phytocompounds isolated from the various solvent extracts of medicinal plants like Cassia fistula, Terminalia bellerica, Tinospora cordifolia, Gymnema sylvestre, and Costus speciosus has been evaluated and proved to possess the therapeutic efficacies against diabetes and cancer. The in-silico approaches utilizing computational tools is coherent to the former in-vitro studies. The research evidence suggests that several key hormones, enzymes and proteins involved in the diabetic and cancer pathways are way more interconnected with the endocrine signaling factors and system. This provides a synergistic therapeutic effect of the phycompounds in diabetic and cancer conditions. The future research focus is based on the identification and crystallization of the pivotal protein receptors involved in insulin signaling and apoptotic pathways through X-ray crystallographic studies. DBT-BIF Centre, Holy Cross College (Autonomous), Tamil Nadu, India is greatly acknowledged for in-silico studies.
- Subjects
TAMIL Nadu (India); INDIA; METABOLIC disorders; DRUG derivatives; ENDOCRINE diseases; TINOSPORA cordifolia; INSULIN receptors
- Publication
Malaysian Journal of Medicine & Health Sciences, 2024, Vol 20, p4
- ISSN
1675-8544
- Publication type
Article