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- Title
ORIGINAL ARTICLE Effects of gender, Helicobacter pylori and hepatitis B virus serology status on cardiovascular and renal complications in Chinese type 2 diabetic patients with overt nephropathy.
- Authors
M. K. W. Lo, Richard I. G.; K.-F. Lee, Richard I. G.; N. N. Chan; W. Y. S. Leung, Richard I. G.; G. T. C. Ko, Richard I. G.; W.-B. Chan, Richard I. G.; W.-Y. So, Richard I. G.; M. C. Y. Ng, Richard I. G.; C.-S. Ho, Richard I. G.; J. S. L. Tam, Richard I. G.; C. W. K. Lam, Richard I. G.; P. C. Y. Tong, Richard I. G.; J. C. N. Chan, Richard I. G.
- Abstract
The aim of this study was to investigate whether chronic infections with Helicobacter pylori and hepatitis B virus (HBV) might affect clinical outcomes in Chinese type 2 diabetic patients with advanced nephropathy. A prospective study of 97 type 2 diabetic patients with clinical proteinuria and renal insufficiency (median serum creatinine 200 µmol/l). During a median follow-up period of 2 years, 34 developed end-stage renal disease (ESRD), 28 had cardiovascular endpoints and 11 patients had died (seven men and four women), and 52.7% developed a combined endpoint. Female patients had longer disease duration, higher blood pressure, lower body weight but higher serum creatinine and spot urine albumin : creatinine ratio as well as lower haemoglobin than male patients. On logistic regression analysis, female gender (hazard ratio: 5.91, p = 0.02), negative H. pylori serology (8.39, p = 0.004), baseline serum creatinine (1.04, p = 0.001) and haemoglobin (1.86, p = 0.01) were independent predictors for ESRD. Systolic blood pressure (1.04, p = 0.003), prior treatment with angiotensin-converting enzyme inhibitors or angiotensin II receptor antagonists (3.41, p = 0.04) and positive hepatitis B surface antigen (4.88, p = 0.025) were independent predictors for cardiovascular endpoints. Female gender (7.89, p = 0.002) and baseline serum creatinine (1.05, p < 0.001) were independent predictors for combined death and cardio-renal endpoints. In Chinese type 2 diabetic patients with clinical proteinuria renal insufficiency, there were high rates of death and cardio-renal outcomes. Female gender, low haemoglobin and negative H. pylori serology were important predictors for ESRD, whereas chronic HBV infection was associated with increased cardiovascular risks.
- Subjects
HELICOBACTER pylori; HEPATITIS B; KIDNEY diseases; DIABETIC nephropathies; DIABETES complications; CARDIOVASCULAR diseases
- Publication
Diabetes, Obesity & Metabolism, 2004, Vol 6, Issue 3, p223
- ISSN
1462-8902
- Publication type
Article
- DOI
10.1111/j.1462-8902.2004.00338.x