We found a match
Your institution may have access to this item. Find your institution then sign in to continue.
- Title
Quantitative Comparison of Functional Contrast From BOLD-Weighted Spin-Echo and Gradient-Echo Echoplanar Imaging at 1.5 Tesla and H<sub>2</sub><sup>15</sup>O PET in the Whole Brain.
- Authors
Lowe, Mark J; Lurito, Joseph T; Mathews, Vincent P; Phillips, Micheal D; Hutchins, Gary D
- Abstract
SummarySpin-echo and gradient-echo echoplanar functional magnetic resonance imaging (fMRI) studies at 1.5 Tesla (T) were used to obtain blood oxygenation level-dependent (BOLD) contrast images of the whole brain in seven strongly right-handed women during execution of a complex motor task. Five subjects underwent subsequent H215O positron emission tomography (PET) studies while performing the same task. Group-averaged results for changes in the MRI relaxation rates R2* and R2 at 1.5T in response to neuronal activation in nine cortical, subcortical, and cerebellar motor regions are reported. Results for each method are grouped according to tissue type-cerebral cortex (precentral gyrus and supplementary motor area), subcortical regions (thalamus and putamen), and cerebellar cortex (superior lobule). The observed changes in R2* from activation-induced oxygenation changes were more variable across brain regions with different tissue characteristics than observed changes in R2. The ratio of ΔR2* to ΔR2 was 3.3 ± 0.9 for cerebral cortex and 2.0 ± 0.6 for subcortical tissue. ΔR2*, ΔR2, and relative blood flow changes were ΔR2* = −0.201 ± 0.040 s−1, ΔR2 = −0.064 ± 0.011 s−1, and Δf/f = 16.7 ± 0.8% in the cerebral cortex; ΔR2* = −0.100 ± 0.026 s−1, ΔR2 = −0.049 ± 0.009 s−1, and Δf/f = 9.4 ± 0.7% in the subcortical regions; and ΔR2* = −0.215 ± 0.093 s−1, ΔR2 = −0.069 ± 0.012 s−1, and Δf/f = 16.2 ± 1.2% in the cerebellar cortex.Journal of Cerebral Blood Flow & Metabolism (2000) 20, 1331-1340; doi:10.1097/00004647-200009000-00008
- Publication
Journal of Cerebral Blood Flow & Metabolism, 2000, Vol 20, Issue 9, p1331
- ISSN
0271-678X
- Publication type
Article
- DOI
10.1097/00004647-200009000-00008