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- Title
Pharmacokinetics of topically applied ciprofloxacin in tears of mesocephalic and brachycephalic dogs.
- Authors
Hendrix, Diane V. H.; Cox, Sherry K.
- Abstract
Objective To evaluate the pharmacokinetics of ophthalmic ciprofloxacin in the tear film of normal mesocephalic and brachycephalic dogs. Animals studied Twenty mesocephalic dogs and 15 brachycephalic dogs. Procedures Thirty-five microliters of ciprofloxacin were placed on the cornea of both eyes of each dog. Five brachycephalic dogs were used twice. A tear-test strip placed in the ventral cul de sac for 30 s was used to obtain samples. The tear film of each eye was sampled once at eight time-points post administration, resulting in five samples at each time-point. Samples were evaluated using high performance liquid chromatography. Data from the two skull types were compared using the unpaired two-tailed t-test. Results The mean concentration of ciprofloxacin in the tears of mesocephalic dogs was 192.8 ± 269.97, 140.6 ± 91.06, 56.60 ± 28.47, 13.6 ± 6.3, 43.25 ± 59.71, 16.6 ± 10.62, 15.6 ± 13.16 and 6.25 ± 9.84 µg/g at 5, 10, 15, 30 min and 1, 2, 4 and 6 h, respectively. The mean concentration of ciprofloxacin in the tears of brachycephalic dogs was 272.6 ± 106.21, 144.4 ± 142.32, 131.2 ± 147.07, 75 ± 80.07, 40.8 ± 30.35, 35 ± 21.98, 52.75 ± 51.87 and 8.6 ± 12.10 µg/g at 5, 10, 15, 30 min and 1, 2, 4 and 6 h, respectively. There was no statistical difference in tear concentration at any time-point between skull types. Conclusions Topical application of ciprofloxacin resulted in a mean tear concentration of ciprofloxacin that remained above the MIC90 levels for most pathogenic bacteria for 6 h in normal mesocephalic and brachycephalic dogs.
- Subjects
PHARMACOKINETICS; CIPROFLOXACIN; TEARS (Body fluid); ANTIBIOTICS; LABORATORY dogs
- Publication
Veterinary Ophthalmology, 2008, Vol 11, Issue 1, p7
- ISSN
1463-5216
- Publication type
Article
- DOI
10.1111/j.1463-5224.2007.00591.x