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- Title
A pilot study of immunotherapy in dogs with atopic dermatitis using a mannan‐Dermatophagoides farinae allergoid targeting dendritic cells.
- Authors
González, José‐Luis; Zalve, Vicente; Fernández‐Caldas, Enrique; Cases, Bárbara; Subiza, José‐Luis; Casanovas, Miguel
- Abstract
Background: Polymerized allergoids coupled to nonoxidized mannan (PM‐allergoids) are novel allergen preparations used for immunotherapy. Objective: To evaluate PM‐allergoids as an alternative immunotherapy for dogs with canine atopic dermatitis (cAD) associated with serological responses to Dermatophagoides farinae allergens. Animals: Sixteen dogs with history and clinical signs of cAD; positive on serum allergen specific IgE testing to D. farinae. Twelve dogs were, in addition, positive to Acarus siro and/or Lepidoglyphus destructor. Methods and materials: A prospective pilot study with no control group. PM‐allergoids were administered by subcutaneous injection over a 10 month period. A pruritus Visual Analog Scale (pVAS) and medication scores were evaluated. Adverse reactions were recorded. Results: The median value of the pVAS of the dogs decreased from 0.6 to 0.2 with a median of 67% improvement over the first three months (P < 0.0001). The individual improvement for each dog was greater than 60%. No major adverse effects were observed. Conclusions and clinical importance: Allergen‐specific immunotherapy using an allergoid coupled to nonoxidized mannan may be an effective alternative for the management of cAD.
- Subjects
ATOPIC dermatitis; IMMUNOTHERAPY; ALLERGENS; FOOD allergy; DERMATOPHAGOIDES
- Publication
Veterinary Dermatology, 2018, Vol 29, Issue 5, p449
- ISSN
0959-4493
- Publication type
Article
- DOI
10.1111/vde.12679