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- Title
Risk compounds, potential mechanisms and biomarkers of traditional Chinese medicine‐induced reproductive toxicity.
- Authors
Li, Qiuju; Yan, Xiaoyu; Zhang, Ying; Zhou, Jie; Yang, Liang; Wu, Shuangyue; Peng, Cheng; Pan, Xiaoqi
- Abstract
With the increasing application of traditional Chinese medicine (TCM), TCM‐induced reproductive toxicity has gradually aroused people's concern. Various TCM, such as Tripterygium wilfordii Hook. f., Radix Aconiti lateralis Preparata and Rhizoma Pinelliae, are currently reported to cause reproductive toxicity in humans and animals. However, a summary of the material bases, mechanisms and biological markers of TCM‐induced reproductive toxicity is still lacking. This review filled the gap by searching and summarising relevant studies and articles published on PubMed, CNKI and Web of Science databases from January 2000 to November 2021. The risk ingredients involved in TCM‐induced reproductive toxicity were divided into glycosides, alkaloids, phenols, terpenoids, anthraquinones, lactones, plant toxin proteins, animal toxins and so forth. Potential mechanisms underlying TCM‐induced reproductive toxicity, including steroidogenic toxicity, lipids metabolism abnormity, energy insufficiency, oxidative stress and apoptosis, were illustrated. We also outlined possible biomarkers, especially biomarkers of effect involved in TCM‐induced reproductive toxicity, including anti‐oxidant enzymes, signalling pathways, genes and growth factors. The risk compounds, possible mechanisms and biomarkers of TCM‐induced reproductive toxicity were reviewed. Here, the risk ingredients are divided into glycosides, alkaloids, phenols, terpenoids, anthraquinones, lactones, plant toxin proteins, animal toxins and uncharacterised compounds of TCM. Additionally, the possible mechanisms of TCM‐induced reproductive toxicity, including steroidogenic toxicity, lipids metabolism abnormity, energy insufficiency, oxidative stress and apoptosis, were illustrated. The possible biomarkers involved in TCM‐induced reproductive toxicity, including anti‐oxidant enzymes, signalling pathways, genes and growth factors, are also outlined.
- Subjects
PLANT toxins; BIOMARKERS; CHINESE medicine; LIPID metabolism; PLANT proteins; ANTHRAQUINONES
- Publication
Journal of Applied Toxicology, 2022, Vol 42, Issue 11, p1734
- ISSN
0260-437X
- Publication type
Article
- DOI
10.1002/jat.4290