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- Title
Estimating Carcinogenic Potency from a Rodent Tumorigenicity Experiment.
- Authors
Finkelstein, Dianne M.; Ryan, Louise M.
- Abstract
SUMMARY Rodent tumorigenicity experiments are conducted to determine whether a particular substance accelerates tumour development. The association between exposure to this substance and the risk of tumour development can be characterized by a measure of carcinogenic potency. The most commonly used potency measure, the dose effect on the lifetime risk of tumour, may be seriously biased, especially when control and exposed groups differ with respect to longevity. However, more appropriate measures, which account for age at death, are largely unavailable except in the special cases of instantly lethal or nonlethal tumours or tumours with observable onset. In this paper, we propose an estimate of carcinogenic potency based on a proportonal prevalence odds model which applies regardless of tumour lethality and can be calculated using standard statistical methodologies. Furthermore, we show how our estimator can be used to generalize available potency estimators to turnouts of any lethality.
- Subjects
TUMOR growth; CARCINOGENICITY testing; STATISTICS
- Publication
Journal of the Royal Statistical Society: Series C (Applied Statistics), 1987, Vol 36, Issue 2, p121
- ISSN
0035-9254
- Publication type
Article
- DOI
10.2307/2347543