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- Title
Editorial: Hormones, Neurotransmitters, and T-Cell Development in Health and Disease.
- Authors
Pérez, Ana Rosa; Mendes-da-Cruz, Daniella Areas; Geenen, Vincent; Savino, Wilson
- Abstract
Highlights from the article: Thymus physiology, T-cell development, and peripheral T-cell homeostasis are controlled by a large variety of soluble molecules and their cognate receptors, targeting both the lymphoid and non-lymphoid compartments. Authors also obtained data compatible with a faster commitment of double negative thymocytes in the thymopoietic process accompanied by an increased thymic output of naïve T cells, this later observation being consistent with a reduction of central memory T cells in secondary lymph organs. Glucocorticoids can act on practically all types of cells, particularly T cells, showing to have upon these cells important immunosuppressive and anti-inflammatory effects, but also affect their phenotype, secretion profile, as well as survival and migratory properties.
- Subjects
NEUROTRANSMITTERS; HORMONES; DRUG side effects; DISEASES; T cells
- Publication
Frontiers in Endocrinology, 2019, p1
- ISSN
1664-2392
- Publication type
Editorial
- DOI
10.3389/fendo.2019.00454