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- Title
Mechanisms and Strategies for Determining m<sup>6</sup>A RNA Modification Sites by Natural and Engineered m<sup>6</sup>A Effector Proteins.
- Abstract
N6‐Methyladenosine (m6A) is the most common internal RNA modification in the consensus sequence of 5′‐RRACH‐3′. The methyl mark is added by writer proteins (METTL3/METTL14 metyltransferase complex) and removed by eraser proteins (m6A demethylases; FTO and ALKBH5). Recognition of this methyl mark by m6A reader proteins leads to changes in RNA metabolism. How the writer and eraser proteins determine their targets is not well‐understood, despite the importance of this information in understanding the regulatory mechanisms and physiological roles of m6A. However, approaches for targeted manipulation of the methylation state at specific sites are being developed. In this review, I summarize the recent findings on the mechanisms of target identification of m6A regulatory proteins, as well as recent approaches for targeted m6A modifications.
- Subjects
RNA modification &; restriction; PROTEINS; PHYSIOLOGY; ADENOSINES; RNA methylation; RNA metabolism
- Publication
Chemistry - An Asian Journal, 2022, Vol 17, Issue 16, p1
- ISSN
1861-4728
- Publication type
Article
- DOI
10.1002/asia.202200367