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- Title
Tandem Radical Cyclization for the Construction of Difluoro‐Containing Oxindoles and Quinoline‐2,4‐diones.
- Authors
Ding, Fangwei; Fang, Yuanding; Jiang, Yanqiu; Lin, Kaifeng; Shi, Lei
- Abstract
Abstract: Cu‐catalyzed direct difluoromethylation of activated alkenes through a difluoromethyl radical addition/cyclization to afford difluorinated oxindoles and quinoline‐2,4‐diones has been developed. This method provides convenient access to a variety of oxindoles and quinoline‐2,4‐diones under mild conditions via a proposed tandem radical cyclization process, while tolerating various functional groups well. Moreover, a facile method to construct diverse difluorinated quinoline‐2,4‐diones by visible‐light photoredox catalysis under mild conditions was presented.
- Subjects
RING formation (Chemistry); OXINDOLES; QUINOLINE; METHYLATION; ALKENES; FUNCTIONAL groups
- Publication
Chemistry - An Asian Journal, 2018, Vol 13, Issue 6, p636
- ISSN
1861-4728
- Publication type
Article
- DOI
10.1002/asia.201701780