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- Title
Stevens–Johnson syndrome/toxic epidermal necrolysis in an orthotopic liver transplant recipient: a case report.
- Authors
Huang, Chun-Sing; Strouphauer, Emily; O'Mahony, Christine; Galván, Nhu T N; Cotton, Ronald; Goss, John; Rana, Abbas
- Abstract
Stevens–Johnson syndrome/toxic epidermal necrolysis (SJS/TEN) is a rare spectrum of acute, mucocutaneous drug reactions characterized by epidermal necrosis of the skin and mucous membranes with progressive multiorgan failure. Cutaneous presentation of SJS/TEN is similar to that of acute graft-versus-host disease, creating a diagnostic dilemma in solid-organ transplant recipients presenting with diffuse, erythematous eruptions, skin sloughing, and systemic sequelae, reflective of both diseases. This case report details a 48-year-old woman post-orthotopic liver transplantation (OLT) who developed a diffuse, painful, morbilliform rash with progressive desquamation, along with corresponding pathological analysis indicative of SJS/TEN. There are few documented reports of SJS/TEN in solid-organ transplant recipients, and this case illustrates successful intervention and resolution of SJS/TEN in an OLT recipient while managing intraabdominal sepsis and an episode of acute rejection. Despite its rarity, prompt diagnosis of SJS/TEN and the implementation of tailored therapeutic strategies are crucial in the care of solid-organ transplant recipients.
- Subjects
STEVENS-Johnson Syndrome; LIVER transplantation; TOXIC epidermal necrolysis; GRAFT versus host disease; MUCOUS membranes; DRUG side effects
- Publication
Journal of Surgical Case Reports, 2024, Vol 2024, Issue 1, p1
- ISSN
2042-8812
- Publication type
Case Study
- DOI
10.1093/jscr/rjad739