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- Title
H<sub>2</sub>O<sub>2</sub> Self‐Supplying CaO<sub>2</sub>/CuO<sub>2</sub>/Fe<sub>3</sub>O<sub>4</sub> Nanoplatform for Enhanced Chemodynamic Therapy of Cancer Cells.
- Authors
Liu, Bojian; Wang, Xiaohui; Yang, Wei; Peng, Hongshang; Zhang, Hongxin
- Abstract
Due to the properties of hypoxia, lower pH, and higher hydrogen peroxide (H2O2) in the tumor microenvironment (TME), a wide variety of metal peroxide nanomaterials have got great attention for efficient TME‐responsive and ‐regulated tumor therapy. However, a single species of metal peroxide is inadequate to realize high effective anticancer therapy. Herein, we have synthesized a hyaluronic acid (HA) modified CaO2/CuO2/Fe3O4 nanocomposite by a simple and flexible strategy. CaO2 can generate H2O2 by reacting with water in slightly acidic TME, and the self‐supplying H2O2 can be catalyzed to generate ⋅OH by both Cu2+ and Fe2+ via Fenton‐type reaction. Strongly oxidizing ⋅OH can induce tumor cells death for enhanced chemodynamic therapy (CDT). The H2O2 self‐supplying and ⋅OH self‐catalyzed nanocomposite exhibited favorable pH‐controlled ⋅OH generation and excellent cancer cells growth inhibition ability, providing a potential nanotheranostics platform with active targeting and favorable therapeutic efficacy in tumor therapy.
- Subjects
CANCER cells; CANCER cell growth; CANCER treatment; HYDROGEN peroxide; CELLULAR therapy; NANOMEDICINE
- Publication
ChemNanoMat, 2024, Vol 10, Issue 4, p1
- ISSN
2199-692X
- Publication type
Article
- DOI
10.1002/cnma.202300540