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- Title
The rate of upgrade for atypical ductal hyperplasia diagnosed on core needle biopsy.
- Authors
Power, J.; Cook, D.
- Abstract
Background: Atypical ductal hyperplasia (ADH) is a clonal proliferation that is associated with a moderately increased risk of breast carcinoma. Current treatment of ADH diagnosed on core needle biopsy (CNB) consists of surgical excision in order to exclude a higher-grade lesion. The number of patients with ADH on core needle biopsy diagnosed with ductal carcinoma in situ (DCIS) or invasive carcinoma upon surgical excision was determined. Design: A retrospective review of cases diagnosed as ADH on CNB between November 1, 2010 and November 1, 2015 was performed. A total of 69 cases from 69 patients were identified. Data collected included patient age, subsequent surgical procedure and pathological diagnosis upon surgical excision. Results: The mean age of patients at the time of diagnosis of ADH on CNB was 54 years. Of the 69 patients, 59 proceeded to excisional biopsy. A total of 34 (58%) were upgraded on surgical excision: 22 (65%) were upgraded to DCIS and 12 (35%) were upgraded to invasive carcinoma. Conclusions: The upgrade rate of ADH initially diagnosed on CNB of 58% is higher than that reported by other institutions which averaged 25%. This discrepancy is of potential interest due to known pathological implications of Newfoundland's unique genetic pool.
- Publication
Canadian Journal of Pathology, 2016, Vol 8, p44
- ISSN
1918-915X
- Publication type
Article