We found a match
Your institution may have access to this item. Find your institution then sign in to continue.
- Title
LOTUS as a novel biomarker of multiple sclerosis.
- Authors
Takahashi, Keita; Tanaka, Fumiaki
- Abstract
Multiple sclerosis (MS) is considered to be an autoimmune demyelinating disorder, but recent studies showed that axonal degeneration is also an important pathological feature of MS. Indeed, Nogo receptor‐1 and its ligands have been identified as key molecules for axonal degeneration in various neurological disorders, including MS. Lateral olfactory tract usher substance, an endogenous Nogo receptor‐1 antagonist, promotes axonal growth and regeneration by blocking Nogo receptor‐1 signaling. We found that the lateral olfactory tract usher substance level in cerebrospinal fluid was inversely correlated with MS disease activity. Here, we review the association between the key molecules in axonal degeneration/regeneration and MS, and discuss the potential application of lateral olfactory tract usher substance as a biomarker and therapeutic target of MS. LOTUS is a promising biomarker to evaluate disease activity in MS and an attractive therapeutic target for inhibition of axonal degeneration and promotion of axonal regeneration.
- Subjects
CEREBROSPINAL fluid; MULTIPLE sclerosis; BIOMARKERS; NOGO receptors; AXONS; NEURODEGENERATION
- Publication
Clinical & Experimental Neuroimmunology, 2019, Vol 10, Issue 1, p27
- ISSN
1759-1961
- Publication type
Article
- DOI
10.1111/cen3.12493