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- Title
Synthesis of Picramide Using Nitration and Ammonolysis in Continuous Flow.
- Authors
Kumar Mittal, Ankit; Prakash, Gaurav; Pathak, Pramod; Maiti, Debabrata
- Abstract
This paper describes a safer, scalable and continuous process for synthesis of picramide. The process consists of two steps: step‐1. nitration of p‐nitroanisole (PNAN) to 2,4,6‐trinitrianisole (TNAN); step‐2. ammonolysis of TNAN to picramide. Both the steps were optimized in flow, with yield of 90% and 98% in step‐1 and step‐2 respectively. Picramide with HPLC purity greater than 99% was obtained. When compared with batch, in step‐1, flow process provided significant advantage in selectivity and yield. The optimized flow process was scaled to 25 g/hr production rate in a laboratory flow reactor. The method can be considered fit for the safe production of picramide at commercial scale.
- Subjects
AMMONOLYSIS; NITRATION; FLOW chemistry; CONTINUOUS processing; HIGH performance liquid chromatography
- Publication
Chemistry - An Asian Journal, 2023, Vol 18, Issue 2, p1
- ISSN
1861-4728
- Publication type
Article
- DOI
10.1002/asia.202201028